Edze

Edze


While it is hard to generalize about their degree of protection, it is possible to make generalizations about their associated fitness costs, which are commonly detected []. A fraction of the population lost one or more anti-mobilome spacer sequences during its cultivation, allowing the transfer of a MGE in this subpopulation and a rapid response to altering selection pressures. Importantly, we show that the cysteine proteinase LmCPb plays a key role in the alteration of NF-kappaB, STAT-1alpha, and AP-1 by promastigote and amastigote infections, ultimately leading to the inability of these TFs to translocate to the nucleus in response to gamma interferon IFN-gamma stimulation and thus contributing to the ability of both parasite forms to effectively block IFN-gamma-mediated nitric oxide NO production in Mphis. CRISPR-Cas systems are found in approximately half of all sequenced bacterial genomes and in nearly all archaeal genomes. Via computational modeling subcomplex structures were proposed that relate to the experimental IMMS data.

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Edze. Edze J. Tijsma's research works in Medicine

Edze


While it is hard to generalize about their degree of protection, it is possible to make generalizations about their associated fitness costs, which are commonly detected []. A fraction of the population lost one or more anti-mobilome spacer sequences during its cultivation, allowing the transfer of a MGE in this subpopulation and a rapid response to altering selection pressures. Importantly, we show that the cysteine proteinase LmCPb plays a key role in the alteration of NF-kappaB, STAT-1alpha, and AP-1 by promastigote and amastigote infections, ultimately leading to the inability of these TFs to translocate to the nucleus in response to gamma interferon IFN-gamma stimulation and thus contributing to the ability of both parasite forms to effectively block IFN-gamma-mediated nitric oxide NO production in Mphis. CRISPR-Cas systems are found in approximately half of all sequenced bacterial genomes and in nearly all archaeal genomes. Via computational modeling subcomplex structures were proposed that relate to the experimental IMMS data.

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